Yasir Al-Aboodi, MD, MPH1, Yasir Alazzawi, MD, MPH2, Ahmed Al-Chalabi, MD, MSc3, Ali Nawras, MD, FACG1
1University of Toledo Medical Center, Toledo, OH; 2University of Massachusetts Medical School, Worcester, MA; 3University of Toledo, Toledo, OH
Introduction: Over many decades, there has been controversy about pancreatic divisum and its association with acute and or chronic pancreatitis. In this study, we used the largest national data registry to examine the relation between pancreatic divisum and the other forementioned pancreatic conditions.
Methods: A retrospective analysis is performed on the National Inpatient Data base (NIS) of 2014 to examine the association between pancreatic Divisum, pancreatitis (Acute and chronic) and pancreatic tumor. Case (Divisum) -control (No divisum) design is created. The no divisum (Control) is selected using the random percentage . The international code for diseases version nine (ICD9)is used to identify all variables. All ages, sex and races were included
Results: 660cases vs 5000 control encounters are identified with a mean age of 49 years. Of the 660, 35.5% (235) male, and 64.5% (426) female. 481(72.9%) are white, 62(9.4%) black, 71(10.8%) Hispanic,19(2.9%) Asians,9(1.4%) Native Americans and 18(2.7%) others. 262/660 (39.7%) in the Divisum group has been found to have a diagnosis of chronic pancreatitis vs.0.6% in the non Divisum group(control). P< .005, OR=103, CI 95% (70-153). 327/660(49%) in the pancreatic divisum group have acute pancreatitis vs 1.4% (70) in the control group. P< 0.000, OR= 70.78, 95% CI (53.081 -94.398) with the adjustment to other risk factors for chronic and acute pancreatitis including smoking, alcohol, cystic fibrosis, TGD pancreatitis, and gallstones pancreatitis and idiopathic pancreatitis. Only 3 cases of pancreatic tumor were detected in the pancreatic Divisum group.
Discussion: There is strong association between Pancreatic divisum and acute and chronic pancreatitis. Yet this association might be influenced by the selection bias from inpatient population only. There is no association found between pancreatic Divisum and pancreatic tumor.
Citation: Yasir Al-Aboodi, MD, MPH; Yasir Alazzawi, MD, MPH; Ahmed Al-Chalabi, MD, MSc; Ali Nawras, MD, FACG. P0917 - IS THERE ASSOCIATION BETWEEN PANCREATIC DIVISUM AND OTHER PANCREATIC CONDITIONS INCLUDING ACUTE PANCREATITIS, CHRONIC PANCREATITIS, AND PANCREATIC TUMORS?. Program No. P0917. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.