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P0917 - Is There Association Between Pancreatic Divisum and Other Pancreatic Conditions Including Acute Pancreatitis, Chronic Pancreatitis, and Pancreatic Tumors?

Monday, October 28

10:30 AM - 4:15 PM

Location: Exhibit Halls 3 and 4 (Street Level)

Presenting Author(s)

YA

Yasir Al-Aboodi, MD, MPH

Toledo, Ohio

Yasir Al-Aboodi, MD, MPH¹, Yasir Alazzawi, MD, MPH², Ahmed Al-Chalabi, MD, MSc³, Ali Nawras, MD, FACG¹

¹University of Toledo Medical Center, Toledo, OH; ²University of Massachusetts Medical School, Worcester, MA; ³University of Toledo, Toledo, OH

Introduction: Over many decades, there has been controversy about pancreatic divisum and its association with acute and or chronic pancreatitis. In this study, we used the largest national data registry to examine the relation between pancreatic divisum and the other forementioned pancreatic conditions.

Methods: A retrospective analysis is performed on the National Inpatient Data base (NIS) of 2014 to examine the association between pancreatic Divisum, pancreatitis (Acute and chronic) and pancreatic tumor. Case (Divisum) -control (No divisum) design is created. The no divisum (Control) is selected using the random percentage . The international code for diseases version nine (ICD9)is used to identify all variables. All ages, sex and races were included

Results: 660cases vs 5000 control encounters are identified with a mean age of 49 years. Of the 660, 35.5% (235) male, and 64.5% (426) female. 481(72.9%) are white, 62(9.4%) black, 71(10.8%) Hispanic,19(2.9%) Asians,9(1.4%) Native Americans and 18(2.7%) others. 262/660 (39.7%) in the Divisum group has been found to have a diagnosis of chronic pancreatitis vs.0.6% in the non Divisum group(control). P< .005, OR=103, CI 95% (70-153). 327/660(49%) in the pancreatic divisum group have acute pancreatitis vs 1.4% (70) in the control group. P< 0.000, OR= 70.78, 95% CI (53.081 -94.398) with the adjustment to other risk factors for chronic and acute pancreatitis including smoking, alcohol, cystic fibrosis, TGD pancreatitis, and gallstones pancreatitis and idiopathic pancreatitis. Only 3 cases of pancreatic tumor were detected in the pancreatic Divisum group.

Discussion: There is strong association between Pancreatic divisum and acute and chronic pancreatitis. Yet this association might be influenced by the selection bias from inpatient population only. There is no association found between pancreatic Divisum and pancreatic tumor.

Demography of pancreatic Divisum

Logistic regression of Pancreatic Divisum, with chronic pancreatitis and Acute pancreatitis with control of sex, smoking, alcohol abuse,Triglceridie and gallstone obstruction

Disclosures:

Yasir Al-Aboodi indicated no relevant financial relationships.

Yasir Alazzawi indicated no relevant financial relationships.

Ahmed Al-Chalabi indicated no relevant financial relationships.

Ali Nawras indicated no relevant financial relationships.

Citation: Yasir Al-Aboodi, MD, MPH; Yasir Alazzawi, MD, MPH; Ahmed Al-Chalabi, MD, MSc; Ali Nawras, MD, FACG. P0917 - IS THERE ASSOCIATION BETWEEN PANCREATIC DIVISUM AND OTHER PANCREATIC CONDITIONS INCLUDING ACUTE PANCREATITIS, CHRONIC PANCREATITIS, AND PANCREATIC TUMORS?. Program No. P0917. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.