Shruti Mony, MD1, Carlos E. Bertran-Rodriguez, MD1, Ishani Shah, MD2
1University of South Florida Morsani College of Medicine, Tampa, FL; 2St. Joseph's Hospital and Medical Center, Creighton University School of Medicine, Phoenix, AZ
Introduction: Pancreatic pseudocysts are a known sequalae of both acute or chronic pancreatitis and are the most common cystic lesions of the pancreas, accounting for 75%-80% of such lesions. The etiology of which resembles the causes of pancreatitis and is more common after alcohol induced pancreatitis. Although the natural history of the diseases has become clearer with the advent of endoscopic ultrasound, there is limited information on its incidence and trends. The aim of our study was to review demographics and clinical characteristics of patients with pseudocysts and determine the recent trends of the rates of hospitalization and associated health care utilization in patients with pseudocysts related to both acute pancreatitis (AP) and chronic pancreatitis(CP).
Methods: A retrospective cross-sectional study of adults (≥18 years) admitted for pseudocyst management (n= 259332) during a five-year period (2010-2014) was performed using the Nationwide Inpatient Sample (NIS). Descriptive analyses were compared using t-test for continuous data and chi-square test for categorical data.
Results: Over the five-year period, the proportion of patients being admitted for pancreatic pseudocyst has been slowly been increasing(Figure 1) from 19.26 to 21.41(p< 0.0003. Among the total population, the mean age at admission was 53.4years, 59.4% were males. Patients with psueodcysts with AP were found to have more risk factors for being overweight and obese compared to CP patients( 1.93, 8.9% vs 1.4 and 5.5%, p< 0.001). Overall, inpatient mortality was higher in the AP group(2.38% vs 1.64; p< 0.005); and was associated with a higher length of stay (mean 11.4 days vs 7.3 days) . On multivariate analysis, advancing age, morbid obesity, comorbidities like ESRD, congestive heart failure, chronic lung disease, metastatic and pancreatic cancer were associated with increased mortality and length of stay in patients with pseudocysts and acute pancreatitis.
Discussion: Pancreatic pseudocysts due to acute pancreatitis is associated with an overall higher inpatient mortality, length of stay and cost of hospitalization compared to chronic pancreatitis. Advance age, morbid obesity, comorbidities like ESRD , congestive heart failure, chronic lung disease, metastatic and pancreatic cancer were associated with increased mortality and length of stay in patients with pseudocysts and acute pancreatitis.
Citation: Shruti Mony, MD; Carlos E. Bertran-Rodriguez, MD; Ishani Shah, MD. P0929 - PANCREATIC PSEUDOCYSTS IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS, TRENDS AND CLINICAL OUTCOMES OF HOSPITALIZATION: INSIGHTS FROM A NATIONAL INPATIENT DATABASE. Program No. P0929. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.