Category: Stroke; Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development)
to assess the efficacy of transcranial direct current stimulation (tDCS) in post-stroke patients diagnosed with chronic aphasia.
double-blind randomized placebo controlled trial
Setting : Casa Colina Hospital and Centers for healthcare
Participants (or Animals, Specimens, Cadavers) :
Our preliminary sample includes 26 post-stroke patients with chronic aphasia (20 males; age: 58±12y; 0.8-18years post-injury; 17 ischemic stroke; 19 non-fluent aphasia). Fourteen patients were in the tDCS group.
In this on-going study, patients are randomly assigned either to the tDCS group or to the sham (placebo) group. Everyone except the principal investigator (CS) is blinded to group assignment. Both groups receive five consecutive days consisting of approximately 20 minutes of tDCS or sham across each session.
Main Outcome Measure(s) :
the Western Aphasia Battery-Revised (WAB-R), Communication Outcomes after Stroke (COAST), and Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39)
Preliminary results demonstrate a significant increase on the auditory-verbal comprehension subscore of the WAB-R in the tDCS group vs. sham group (F=6.82; p=0.02), while an increase on the total score of the COAST was observed in both groups (F=10.67; p<.01). No significant changes were observed on the total score of the SAQOL-39.
Our findings suggest an improvement in language functions, particularly among receptive language skills, in response to treatment (vs. placebo). Interestingly, improvements in communication were subjectively perceived by patients in both groups<./p>
Caroline Schnakers– Assistant Director, Research Institute, Casa Colina Hospitals and Centers for Healthcare, Pomona, California
Henry Millan– Research associate, Research Institute, Casa Colina Hospitals and Centers for Healthcare, Pomona, California
Sharon Lee– Speech therapist4v, Casa Colina Hospitals and Centers for Healthcare, Pomona, California
Melissa Howard– Speech therapist, Casa Colina Hospitals and Centers for Healthcare, Pomona, California
Emily Rosario– Director of the Research Institute, Casa Colina hospital and Centers for Healthcare, Los Angeles, California