Category: Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development); Health Services Research
Objective(s) : To compare the effect of platelet-rich plasma therapy and oxygen-ozone injections on decreasing pain and increasing function in patients with knee osteoarthritis.
Data Sources : EBSCO, (Academic Search Ultimate, Medline, CINAHL) researched between 8/30/18 - 1/17/2019
Study Selection : Four individuals performed a search of the literature using EBSCO (Academic Search Complete, Academic Search Ultimate, Medline, and CINAHL) between August 30, 2018 and September 1, 2018 as well as January 17, 2019. Titles and abstracts were initially reviewed, followed by an analysis of the full text with the inclusion and exclusion criteria of PEDRO score 5 or greater; application of at least one of the following intra-articular knee injections: platelet-rich plasma or oxygen-ozone; Kellgren-Lawrence Classification I-III OR Ahlback Scale of I-II; knee pain measured using VAS and/or function measured using WOMAC.
Data Extraction : Of the 143 articles obtained through the searches, 14 peer-reviewed articles were extracted which met the inclusion and exclusion criteria in order to be included in the systematic review.
Data Synthesis : Platelet-rich plasma (PRP) injections were found to have a greater impact on decreasing pain and increasing function while continuing to be effective for a longer period of time when compared to oxygen-ozone injections via VAS and WOMAC scores.
Conclusions : In conclusion, PRP is superior to oxygen-ozone injection therapy in decreasing pain and improving function based on VAS and WOMAC scores. Patients with mild to moderate knee osteoarthritis should consider PRP injections over oxygen-ozone injections due to its increased duration of improvements in pain and function.
Richard Haydt– PT Faculty, Misericordia University, Dallas, Pennsylvania
Bridget Boyle– Student, Misericordia University, Dallas, Pennsylvania
Megan Meyers– Student, Misericordia University, Lancaster, Pennsylvania
Samantha Weissberg– Student, Misericordia University, Dallas, Pennsylvania
Kristian Dyrli– Student, Misericordia University, Dallas, Pennsylvania