Category: Stroke; Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development); Measurement
Brain derived neurotrophic factor (BDNF) has been shown to play an important role in the pathophysiology of poststroke depression (PSD). The aim of this study was to determine whether or not the BDNF Val66Met genotype is associated with functional outcome of poststroke and poststroke depression patients in an inpatient rehabilitation sample.
The genotypes for BDNF SNP Val66Met for individuals with stroke were obtained from the Partners HealthCare Biobank Portal. Depression was diagnosed using Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) criteria. The main outcome measures were the Functional Independence Measures (FIM). Univariate and multivariate analysis were performed using logistic regression analysis.
The setting is in the Spaulding rehabiliation hospital.
Participants (or Animals, Specimens, Cadavers) : One hundred and eleven individuals who were admitted for inpatient rehabilitation following a stroke and enrolled in the Partners HealthCare Biobank.
Interventions : Not applicable.
Main Outcome Measure(s) : The primary outcome was function, measured using Functional Independence Measure (FIM) as part of standard clinical care.
Our results showed a significant association between BDNF Met alleles and risk for PSD (OR=0.34, 95% CI: 0.13-0.92, P=0.034) after adjusting for confounder variables, but no differences were observed in genotype distribution (P=0.060). Multivariate logistic regression analysis confirmed BDNF Met alleles as a risk factor for lower motor functional outcome (OR=2.42; 95% confidence interval: 1.09-5.40; P=0.031), especially lower memory functional scores (B=0.68; 95% CI: 0.10-1.26; P=0.022).
The present study suggests that the BDNF Met allele may provide valuable prediction for the occurrence of PSD. PSD with the BDNF Met allele may impede stroke recover, especially memory function.
Zhenxiang Han– NA, Seventh People's Hospital of Shanghai University of TCM/spaulding rehabilitation hospital, Charlestown, Massachusetts