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Oral Session
Medical Nutrition
Alicia Sneij Perez, MS
Florida International University
Adriana Campa, PhD, MBD, RD
Florida International University
Leslie Seminario, MS
Florida International University
Sabrina Martinez, PhD
Florida International University
Fatma Huffman, Ph.D., R.D.
Florida International University
Mary Jo Trepka, MD
Florida International University
Florence George, PhD
Florida International University
Marianna Baum, PhD
Florida International University
Objectives : The objective of this study is to assess the effectiveness of a 6-month nutrition intervention to improve glycemic parameters and inflammation in prediabetic PLWH on stable ART with undetectable HIV viral load.
Methods : A 6-month randomized, controlled nutrition intervention was conducted in prediabetic PLWH. The study participants for the intervention were recruited from the Miami Adult Studies for HIV (MASH) cohort at the FIU-Borinquen Research Clinic. Upon their consent, the participants were randomized into the intervention group or the control group. Participants randomized in the intervention group met once a month for approximately 1 hour where they received medical nutrition therapy, nutrition counseling and nutrition education; participants randomized into the control group received educational material at baseline. Blood was drawn at baseline and at 6-month to measure fasting blood glucose (FBG) and high sensitivity C-reactive protein (hs-CRP).
Results : A total of 38 participants were recruited and randomized into either the intervention group (n=20) or the control group (n=18). We found that the FBG for the 6-month follow-up for the intervention group was significantly lower than the baseline FBG values of the same study group (paired t-test; p=0.031). No significant difference was found in the control group between the baseline and 6-month fasting blood glucose values (p=0.068). Moreover, no significant difference was found in pre/post C-reactive protein (CRP) levels in the intervention or control group (paired t-test; p=0.404 and p= 0.117 respectively). There was a significant difference in CRP levels at baseline (p=0.028) between the study groups but no difference at the 6-month follow up (Mann Whitney U test: p=0.430).
Conclusions : The results from this intervention support the notion that a nutrition intervention is effective in prediabetic PLWH to lower diabetes risk by significantly lowering fasting blood glucose and may be implemented into larger scale interventions; however, no significant changes was seen in hs-CRP values between the 2 groups.
Funding Sources : National Institute of General Medical Sciences (NIGMS): Research Initiative for Scientific Enhancement (RISE), Biomedical Research Initiative (BRI) Grant, National Institute on Drug Abuse 5U01DA040381-03 and FIU-Dissertation Funding.