Topical Area: Obesity, Aging and Chronic Disease
Objectives : Dysfunction of the HPA axis, as evidenced by alterations in the diurnal salivary cortisol rhythm, has been shown to contribute to the pathophysiology of obesity both directly by skewing body composition and indirectly by altering appetite and microbiome. The aim of this study was to assess the impact of a laboratory and clinical-guided dietary supplemental protocol on HPA axis dysfunction.
Methods : This study examines a cohort of 703 patients utilizing a clinical analysis of 1. Hypothalamic-pituitary-adrenal axis tests which were 4 point salivary cotisol, 2 point salivary DHEA, and 6 urinary neurotransmitters. 2. Self-reported Quality of Life questionnaire 3. Personalized dietary supplementation with neurotransmitter amino acid precursors and/or adrenal support monitored for 8 months.
Results : Pre and post test demonstrated improved sleep quality (47%, p< 0.05); increased serotonin by 172% (p< 0.05); increased norepinephrine (p< 0.05); improved adrenal tone with increased morning cortisol (p< 0.05) and decreased evening cortisol (p< 0.08).
Conclusions : A personalized medicine approach consisting of symptom analysis, noninvasive laboratory testing and dietary supplementation improved parameters of HPA axis dysfunction. Lab-guided personalized medicine may be able to diagnose early and treatable HPA axis dysfunction and in this way curtail a known pathway to obesity.
Funding Sources : No grant funding was received. The research is an IRB-exempted analysis of data collected by Sanesco International, Inc.