Topical Area: Dietary Bioactive Components
Objectives : In this study we want to investigate the effects of Q-CAN® Plus, the nutritional fermented soy drink on the serum lipid profile of lean and obese individuals.
Methods : Prospective study comprised of lean (10) and obese (10) individuals without a known diagnosis. 11 clinic visits over 14 weeks. Visits 1, 2 and 3 occurred prior to treatment. 237ml of soy was dispensed at visit 3 and was consumed twice daily for 4 weeks until visit 7 (weeks 1-4). Visits 8, 9, 10 and 11 were post treatment. Blood was collected during visits 1, 3, 5, 7, 8, 9, 10,11. Serum from blood samples were subjected to quantification of lipid parameters including: Total cholesterol, LDL cholesterol, and HDL cholesterol, at a clinical chemistry lab (Yale New Haven Health, Yale University, CT, USA). The results were obtained and statistical analysis was performed employing paired t-test and one-way ANOVA (significance of p< 0.05). Data analysis was conducted for the three therapeutic phases of pretreatment, during treatment and post treatment.
Results : Obese and lean subjects had a significant decrease in total cholesterol levels during intake of as compared to pre-treatment (mean obese mg/dl, pre=162.7, on=150.1, P< 0.0048; lean, pre=167, on=151.5 P< 0.0260) and LDL cholesterol (mean obese, pre=105.4, on=88.4 P< 0.0304; mean lean pre=102.7 on=80.3 P< 0.0059). Post treatment total cholesterol and LDL cholesterol values trended towards baseline. No significant changes were observed in HDL and triglyceride. We also compared the percentage change in lipid parameters using pre-treatment as a reference. Q-CAN® Plus consumption in obese subjects resulted in a 16% reduction in LDL, and a 7% reduction in total cholesterol levels, while in lean it resulted in a 7% decrease in LDL and 9% reduction in total cholesterol levels (P,).05). The percentage change post-treatment was not significant.
Conclusions : Q-CAN® Plus had hypolipidemic effect in obese and lean individuals, specifically on total and LDL cholesterol. These preliminary observations are promising for the dietary benefits of Q-CAN® Plus with respect to reducing the risks from cardiovascular diseases. Future studies need to confirm this effect, particularly in subjects with dyslipidemia.
Funding Sources : Beso Biological Research, Inc.