Topical Area: Dietary Bioactive Components
Considering the disorder of lipid metabolism and iron deposition in alcoholic liver (ALD), ferroptosis may play a vital role in its pathogenesis. In the present research, we sought to determine whether ferroptosis occurred in ALD and is associated with increased mitochondria-endoplasmic reticulum interaction (MAMs) through RNA-dependent protein kinase like ER kinase (PERK) upregulation and whether quercetin plays a role in ferroptosis.
Our preliminary results temporarily focused on animals model. Adult male C57BL/6J mice were isocalorically pair-fed either a regular or ethanol-containing Lieber De Carli liquid diets (28% energy replacement) supplemented with quercetin (100 mg/kg.bw) or not for 12 weeks.
Our results are preliminarily illustrated enhanced ferroptosis regulated by increased MAMs through PERK upregulation in ALD. And quercetin protected hepatocyte from ethanol toxicity by reversing above changes.
Funding Sources :
National Natural Science Foundation of China No. 81673164