Topical Area: Methods and Protocols
Microneedles (MN) and iontophoresis are innovative approaches for transdermal delivery of drugs and bioactive compounds. They can make the treatment tolerable, safe, and convenient. Nanoparticles (NPs) can enhance solubility, stability and prolonged release of many drugs and bioactive compounds and deliver them to specific cells. In the present study, we determined the delivery efficacy of dye-loaded lipid NPs using MN, iontophoresis and their combination, in an in vitro skin permeation study.
Results : The penetration of fluorescent dye through the skin layers was increased and reached to the subcutaneous adipose tissue following increment of MN length (1.5mm >1mm >0.5mm), time and combined treatments. Combination of MN and iontophoresis resulted in increased dye intensity in the dermis and subcutaneous adipose tissue over time.
Funding Sources :
NIH (Grant R15AT008733).