Topical Area: Sports Nutrition
Objectives : This study was designed to evaluate the efficacy of an herbal blend composed of Sphaeranthus indicus and Mangifera indica extracts to improve muscle health.
Methods : In a randomized, double-blind, placebo-controlled study, 40 male participants of 18-40 yrs age, were assigned to receive 650 mg of LI12542F6 (A) or Placebo (P) for 56 days. The primary endpoint was change from baseline in muscle strength, assessed by 1-RM Bench and Leg presses. Secondary endpoints included muscle endurance, time to exhaustion, muscle size, body composition and free testosterone. Safety was also assessed.
Results : Significant (p< 0.0001) increases in change from baseline for strength (bench and leg presses and grip strength) were observed in the A vs. P group beginning at 14 d and continuing throughout the study. Muscle endurance and time to exhaustion were similarly increased by 14 d and continued for the remainder of the study. By day 56, the mid upper arm circumference was statistically increased in A vs. P (p< 0.05) in left and right arms.
Conclusions : Significant improvements in muscle endurance and strength were observed in resistance trained healthy men consuming LI12542F6 daily for 56 days. Further research will elucidate efficacy in other populations.
Funding Sources : Laila Nutraceuticals