Topical Area: Dietary Bioactive Components
Diabetic Retinopathy is the leading cause of blindness, stimulating the rise in 20,000 cases in the United States per year, and leaving over 3 million individuals vulnerable at risk. During the early stages of Diabetic Retinopathy, inflammatory and innate immune responses are derived from pattern-recognition receptors (PRRs) expressed as Advanced Glycation End-products (AGEs). It has been observed that AGEs increase the progression of retinopathy in patients enduring the early stages of retinopathy. The reason behind the complication progression induced by AGEs is the ligand – receptor binding with the Receptor Advanced Glycation End-products. Therefore, by instituting macular carotenoids and curcumin bind with RAGE, may prevent the ligand-receptor binding between RAGEs and AGEs. The following study analyzes carotenoids and polyphenols interacting with the RAGE receptor utilizing computational docking simulations.
A docking program, AutoDock Tools and AutoDock Vina, were used to determine the binding affinity and rmsd (root mean square deviation) values of the carotenoids and curcumin.
It was found that Lutein, Curcumin and Zeaxanthin were able to bind to the RAGE receptor with a strong binding affinity. Lutein had the strongest binding affinity interaction with the RAGE receptor followed by zeaxanthin compared with control [RAP, Receptor associated protein].
RAGE may be of importance in the prevention and management of diabetes complications, and by instituting carotenoids and curcumin as a treatment, this may potentially decrease the progression of diabetes complications.
Funding Sources : None