Topical Area: Community and Public Health Nutrition
B12 is an essential nutrient for brain function. We document what effect does B12 supplementation has on mental health.
The study used 4 years of accumulated data, n=5003, of unique individuals who took the Depression and Anxiety Assessment Test (DAAT), registration TX 7-398-022. That test assessed depression, demographics and also asked about intake of B12 supplements, B12 rich foods and B12 supplemented foods. The depression levels were classified according to the DSM-5 [The Diagnostic and Statistical Manual of Mental Disorders Volume 5] into 4 categories as none (0-6), mild (7-10), moderate (11-19) or severe (20 or more).
N=5003 took the DAAT test, that group mean age was 45, SD 17 and 67.7% were females, 64% Caucasian, 12.2% Hispanic, 8.6% black and 6.8% Asian.
From the n=5003 individuals that took the test, n=2640, 52.8%, reported taking B12 daily twice a day, that group had a mean depression score of 10.1, SD 7.8, and median 9. N=1038, 20.7%, reported taking B12 occasionally, that group had a mean depression score of 10.6, st dev 7.8, and median 10. N=1325, 26.5%, reported rarely taking B12, that group had a mean depression score of 10.3, st dev 8.3, and median 9.
The three groups regardless of their patterns of intake of B12 had similar levels of depression. This, however, does not imply that B12 does not have an effect on the nervous system and 1/4 of the participants did not take enough B12. The liver is known to store a significant amount of B12, which we hypothesize is the reason for the individuals in this study not being significantly affected by B12 intake in the short term.
Funding Sources : Self funded.