Topical Area: Dietary Bioactive Components
The correlation of nutritional patterns with number and types of gastroesophageal refluxes is poorly studied yet.
Aim: To assess the effect of actual nutrition of GERD patients on the number and type of gastroesophageal reflux detected with 24-hours esophageal pH-impedance.
Methods : One hundred twenty-four GERD patients (54 men, age (M±m): 46±17.7 y.o., BMI 28.5±0.6 kg/m2) and 41 healthy controls (8 men, age 42±12.4 y.o., BMI 28.3±1.3 kg/m2) were examined with the use of language-specific food frequency questionnaire and 24-hours esophageal pH-impedance (Ohmega, MMS; 2 pH, 6 impedance catheters, Unisensor). The correlation analysis between macro- and micronutrient consumption and the number of gastroesophageal refluxes (GER), their acidity and duration was performed (Statistica 10, StatSoft)
Direct medium-strength correlation was found between esophageal acid exposure time and the energy value of the ration (Spearman rank R=0.19, p< 0.05), and the amount of consumed fat (R=0.2, p< 0.05).
There was a direct correlation of the total number of GERs with the energy value of the ration (R=0.35, p< 0.05), protein (R=0.3, p< 0.05), fat (R=0.33, p< 0.05), and alcohol consumption (R= 0.28, p< 0.05) and the inverse one with the dietary fiber consumption (R=-0.22).
Significant direct correlation was found between the number of acid GERs and total energy value of the ration (R=0.35, p< 0.05), consumption of fat (R=0.32, p< 0.05), protein (R=0.25, p< 0.05), carbohydrates (R=0.24, p< 0.05) and alcohol (R=0.24, p< 0.05).
Number of weak-acid GERs showed direct correlation with the calories intake (R=0.22, p< 0.05), fat (R=0.21, p< 0.05), protein (R=0.22, p< 0.05), alcohol (R=0.23, p< 0.05) consumption, and the inverse one with the amount of dietary fiber intake (R=-0.24, p< 0.05). Number of high GERs correlated directly with the amount of fat (R=0.3, p< 0.05), protein (R=0.22, p< 0.05), alcohol (R=0.25, p< 0.05) consumed, and inversely with the amount of dietary fiber (R=-0.25, p< 0.05) in the ration.
Paired comparison of the correlation coefficients was performed, but didn’t reveal any difference.
Conclusions : High energy value, consumption of fat and alcohol showed direct medium-strength correlation with esophageal acid exposure and number of GERs. Dietary fiber consumption correlated inversely with total number, weak acid and high GERs.
Funding Sources : Federal research Center of Nutrition and Biotechnology, Russian science foundation