Aging and Chronic Disease
In vitro and animal experiments suggest that resveratrol (RVS) could improve bone health by alleviation of bone mineral and strength loss. However, there has been no epidemiologic evidence linking habitual resveratrol consumption with fracture risk. The aim of the study was to testify the association of habitual RSV consumption with hip fracture risk in Chinese elderly.
Methods : This was a 1:1 age- and gender- matched case–control study among Chinese elderly. Eligible cases were newly diagnosed (within 2-week). Dietary survey was conducted by a 79-item validated food frequency questionnaire. The habitual intake of RSV was estimated as the sum of trans-and cis-resveratrol and trans- and cis-piceid based on the available database of Phenol Explorer. Multivariate conditional logistic regression was applied to examine the relationship of dietary RSV and RSV rich foods with the risk of hip fracture.
Results : A total of 1070 pairs of hip fracture incident cases and controls were included in the analysis, with an average age of 70.6 y and body mass index (BMI) of 22.5 kg/m2. The controls were recruited from both community (82.3%) and hospital (17.7%). The average total RSV intake was 178.6 μg/d and 96.6% participants had no habitual red wine consumption. After adjustment of a range of potential confounders, comparing with the lowest quartile, the highest quartile group had a reduced hip fracture risk by 80.2% (OR: 0.198, 0.099~0.394) for total RSV, and 46.7% (OR: 0.533, 0.319~0.890) for grapes intake in a significant dose-response manner across the quartiles (all P for trend < 0.001). Similar findings were observed for cis- and trans-RSV, as well as cis- and trans-Piceid. Sensitivity analysis with exclusion of patients with chronic disorders made little change in the results. Subgroup analyses indicated that the findings were consistent across gender (men and women), BMI (below or above median), physical activities (below or above median), supplementation of calcium (yes or no), as well as habitual tea drinking (yes or no).
Conclusions : Our findings indicated that higher dietary RSV was associated with a reduced risk of hip fracture in Chinese elderly. As dietary intake of RSV is modifiable, this finding would be of public health importance with respect to fracture prevention in elderly.
Funding Sources :
This work was jointly supported by the National Natural Science Foundation of China (Grants 81773416, 30872100 and 81072299).