Head and Neck Cancer

Panel 25 - (INTERACTIVE) Modern Therapy in Oropharyngeal Cancer: What is the Evidence for Immediate Implementation of Differing Strategies based upon HPV Status?

Moderator(s)

• 

  Thomas Galloway, MD

  Fox Chase Cancer Center
• 

  Matthew Katz, MD, FASTRO

  Lowell General Hospital

This session will provide an overview of strengths/limitations of available studies and discuss ways to implement modern therapy in the era of HPV. The attendees will learn the current strategies for de-escalation and escalation in HPV-positive and HPV-negative oropharyngeal cancers. In addition, the session will provide evidence-based practices de-escalation or escalation strategies off protocol or on clinical trials. Finally, the practical ways to reconcile conflicting results from different studies will be addressed.

After moderators provide an overview, speakers will focus upon four topics:
- Treatment on and off protocol
- Treatment de-escalation strategies for HPV-positive tumors
- Treatment escalation with novel therapeutics for HPV-negative tumors
- Role of chemotherapy in early-stage disease treated with radiation

Learning Objectives:

• Identify evidence based use of de-escalation for HPV+ oropharyngeal cancer
• Identify evidence based use of escalation for HPV- oropharyngeal cancer

Presentations:

• 1:15 PM - 1:20 PM

  Introduction
  Speaker: Matthew Katz, MD, FASTRO – Lowell General Hospital
  
• 1:20 PM - 1:35 PM

  When/if we should treat on- and off-protocol
  Speaker: Loren Mell, MD – University of California, San Diego
  
• 1:35 PM - 1:50 PM

  De-escalation for HPV-Positive Oropharygeal Cancer Radiation Therapy
  Speaker: C Jillian Tsai, MD, PhD, MS – Memorial Sloan Kettering Cancer Center
  
• 1:50 PM - 2:05 PM

  The role of chemotherapy in early stage oropharyngeal cancer
  Speaker: Cristina Rodriguez, MD – University of Washington
  
• 2:05 PM - 2:20 PM

  Escalation strategies with novel therapeutics for HPV-negative and advanced oropharyngeal cancer
  Speaker: Nancy Lee, MD, FASTRO – Memorial Sloan Kettering Cancer Center
  
• 2:20 PM - 2:30 PM

  Audience Q&A
  Speaker: Matthew Katz, MD, FASTRO – Lowell General Hospital