Genitourinary Cancer

Panel 20 - (INTERACTIVE) Brachytherapy Boost for Prostate Cancer: Magic Bullet or Risky Tool?

Chair(s)

• DK

  Daniel Krauss, MD

  Oakland University William Beaumont School of Medicine

This session will focus on the latest evidence on the benefits and harms of brachytherapy boost as part of a combination approach for high risk prostate cancer. This is a high profile topic based upon the results of ASCENDE-RT, which showed a marked improvement in biochemical progression free survival at the expense of higher GU toxicity, igniting debate among radiation oncologists. Presenters will highlight the evidence for brachytherapy boost and compare the evidence in support of alternative options. The panelists include both brachytherapy boost supporters and a speaker who interprets the recent clinical trials to not support brachytherapy boost, with the goal of providing a broad perspective rather than a debate format. Dr. Hoskin will review the current evidence for prostate brachytherapy, including his trial of prostate HDR brachytherapy boost. Dr. Spratt will provide a perspective on the urinary toxicity of prostate brachytherapy and the need to weigh that against the PSA failure free survival benefits. Dr. Krauss will provide an overview of various brachytherapy approaches in the combination and monotherapy settings and present emerging concepts in brachytherapy.

Learning Objectives:

• To describe the latest evidence on the benefits and harms of prostate brachytherapy boost for the treatment of men with high-risk prostate cancer.
• To differentiate expected outcomes after different approaches for radiation boost for high-risk prostate cancer.
• To discuss which patients may benefit from the addition of brachytherapy boost for prostate cancer.

Presentations:

• 11:15 AM - 11:30 AM

  Introduction
  Speaker: Daniel Krauss, MD – Oakland University William Beaumont School of Medicine
  
• 11:30 AM - 11:45 AM

  Prospective Evidence to Support Prostate Brachytherapy Boost
  Speaker: Peter Hoskin, MD – Mount Vernon Hospital
  
• 11:45 AM - 12:00 PM

  Prostate Brachytherapy Boost is not a preferred option
  Speaker: Daniel Spratt, MD – University of Michigan
  
• 12:00 PM - 12:15 PM

  Prostate Brachytherapy Approaches in Combination and Monotherapy Settings
  Speaker: Daniel Krauss, MD – Oakland University William Beaumont School of Medicine
  
• 12:15 PM - 12:30 PM

  Audience Q&A
  Speaker: Daniel Krauss, MD – Oakland University William Beaumont School of Medicine