Special Session

EDU 22 - Recruitment to Difficult Randomized Clinical Trials: Lessons from PARTiQoL, VALOR, and ProtecT

Chair(s)

• 

  Drew Moghanaki, MD, MPH

  Veterans Affairs - Atlanta

Introduction
- Overview of session, and brief explanation of evidence underpinning the session's content

Lessons from PARTIQoL
- Describe the recruitment challenges of this NCI-funded phase III RCT of Proton Therapy vs IMRT for prostate cancer, and how they are being addressed and overcome.

Lessons from VALOR
- Describe the recruitment challenges of this VA-sponsored phase III RCTs of Surgery vs SBRT for stage I lung cancer, and the methods that have contributed to it's successful recruitment.

Lessons from ProtecT
- Describe the strategies developed at the University of Bristol that helped complete the first successful phase III RCT of Surgery vs Radiotherapy vs Active Monitoring for prostate cancer (n=1,600, NEJM 2016).
- Describe the QuinteT Recruitment Intervention (QRI) model that was used for ProtecT, and how it has helped other difficult RCTs that were close to early termination turn around its accrual, and successfully complete. (QRI is now in >25 RCTs around the world).

Summary/Questions
- Provide attendees an opportunity to discuss concerns/queries about particular RCTs they are working on, and ways in which the techniques discussed in the session may be applied to address these.

Learning Objectives:

• Recognize hidden challenges with recruitment to difficult randomized trials
• Describe strategies to improve recruitment to difficult randomized trials

Presentations:

• 8:00 AM - 8:20 AM

  Lessons from PARTIQoL
  Speaker: Jason Efstathiou, MD, PhD – Massachusetts General Hospital
  
• 8:20 AM - 8:40 AM

  Lessons from VALOR
  Speaker: Drew Moghanaki, MD, MPH – Veterans Affairs - Atlanta
  
• 8:40 AM - 9:00 AM

  Lessons from ProtecT
  Speaker: Jenny Donovan, PhD – University of Bristol