Presentation Authors: Bethany Laden*, Amanda De Hoedt, April Scharfenberg, Roopali Saxena, Justin Senechal, Durham, NC, Catherine Bresee, Jayoung Kim, Stephen Freedland, Jennifer Anger, Los Angeles, CA
Introduction: Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) has been associated with psychosocial factors and non-urological associated somatic syndromes (NUAS) such as fibromyalgia, irritable bowel syndrome (IBS), and chronic fatigue. We examined the prevalence of comorbid conditions in a heterogenous population of men and women with IC/BPS in a national dataset.
Methods: Using the Veterans Affairs Informatics and Computing Infrastructure (VINCI), we identified a random sample of patients with an ICD-9 diagnosis of IC/BPS and patients without an ICD-9 diagnosis of IC/BPS or other pelvic pain conditions by querying all living veterans in the VINCI system. Presence of eleven comorbidities was determined using ICD-9 diagnosis codes: Alcohol Abuse, Back Pain, Chronic Fatigue, Diabetes, Fibromyalgia, Irritable Bowel Syndrome, Migraines, Post-Traumatic Stress Disorder (PTSD), Sexual Trauma, Smoking and History of Depression. Differences between groups were tested using multivariable logistic regression where needed to adjust for age.
Results: Data from 2,056 subjects were included in this analysis with 1,211 IC/BPS patients (538 males, 44% and 673 females, 56%) and 845 non-IC/BPS patients (424 males, 50% and 421 females,50%). IC/BPS patients were more likely to be female (p=0.01) and were significantly older at the time of abstraction (p < 0.0001). After adjusting for the significant difference of age, the predicted prevalence of most comorbidities was higher in IC/BPS subjects (Table 1). For example, 41% of IC/BPS patients in our dataset were diagnosed with NUAS vs. 16% in non-IC/BPS patients. IC/BPS patients were nearly twice as likely to have a sexual trauma diagnosis (7% vs. 3%, p < .0001) and 1.4 times more likely to have a PTSD diagnosis (40% vs. 30%, p < .0001).
Conclusions: A significant percentage of IC/BPS patients were diagnosed with NUAS, which was consistent with the 47% found in a 2014 study by the MAPP Network (Krieger, et al.). Our PTSD findings in 40% of IC/BPS patients supports the findings of one of the few studies to examine the relationship between PTSD and IC/BPS, which reported 42% prevalence (McKernan, et al.). These data further elucidate the comorbidities associated with IC/BPS in male and female patients.
Source of Funding: CDC Grant U01DP006079