Presentation Authors: Tomohiro Matsuo*, Yasuyoshi Miyata, Tsutomu Yuno, Kyohei Araki, Yuichiro Nakamura, Yuji Sagara, Kojiro Ohba, Hideki Sakai, Nagasaki, Japan
Introduction: Although overactive bladder (OAB) is primarily treated using anticholinergic drugs and Î²3 adrenergic stimulants, patients are concerned regarding adverse events like dysuria, dry mouth, constipation, and fluctuation of blood pressure, and there is a particular desire for the emergence of safe treatments for elderly patients.Chronic high salt intake is closely related to lifestyle diseases, such as hypertension and diabetes, which have a significant influence on the development of OAB. However, there are no studies that examine the impact of salt reduction, a representative element of lifestyle disease, on the OAB symptoms. This study aimed to analyze the therapeutic effect of reducing salt intake in OAB patients.
Methods: The subjects were OAB patients with excessive salt intake (â‰¥8 g/day for men and â‰¥7 g/day for women). OAB was defined as an overactive bladder symptom score (OABSS) of â‰¥2 points for Q3 (urgency) and a total score of â‰¥3 points. The subjects were provided nutrition guidance related to salt reduction every four weeks using brochures. We prospectively examined urinary symptoms at the start of salt reduction and 12 weeks into salt reduction using OABSS and the frequency volume chart (FVC). The daily salt intake was estimated by examining the sodium and creatinine concentrations of spot urine samples using a formula that was adjusted for body height, body weight, and age. Value of P < 0.05 was considered statistically significant.
Results: A total of 98 subjects (52 men), with a mean age of 66.7 Â± 11.5 years were evaluated. During the observation period, 71 subjects (72.4%) achieved salt reduction (Success [S] Group), while 27 subjects (27.6%) did not (Failure [F] Group]. With respect to the OABSS, the S Group demonstrated an improvement in not only Q1 (daytime frequency) and Q2 (nocturia) from 1.2 Â± 1.0 to 0.6 Â± 1.0 (P < 0.001) and from 2.1 Â± 0.5 to 1.4 Â± 0.7 (P < 0.001), respectively, but also in Q3 (urgency), Q4 (urgency incontinence), and total score from 2.3 Â± 0.5 to 2.0 Â± 0.7 (P < 0.001), from 1.3 Â± 1.0 to 1.1 Â± 1.0 (P=0.003), and from 6.9 Â± 1.0 to 5.1 Â± 2.2 (P < 0.001), respectively.With respect to FVC, the S group showed improvement in voided volume from 247.8 Â± 25.1 mL to 260.4 Â± 32.6 mL (P < 0.001), and nocturia from 2.5 Â± 1.0 times to 1.6 Â± 0.9 times (P < 0.001). The F group showed no improvement in any of the parameters of OABSS and FVC.
Conclusions: Salt intake reduction in OAB patients with excess salt intake would be a beneficial treatment option. We also believe that salt restriction would be a good approach in cases of OAB with excessive salt intake that does not respond to treatments, including drug therapy.