Presentation Authors: Alex Galante*, Gainesville, FL, Thomas Masterson, Mohit Butaney, Miami, FL, Alexander Pastuszak, Salt Lake City, UT, Hossein Sadeghi-Nejad, Newark, NJ, Ranjith Ramasamy, Miami, FL
Introduction: Collagenase clostridium histolyticum (CCH, Xiaflex) is the only FDA-approved medication for treatment of Peyronie's disease since 2013. It is unclear how practitioners actually use CCH in their own practices. The objectives of the study were: 1) to identify variability in practice patterns for CCH among practitioners, 2) to assess adherence to the package insert instructions and 3) to evaluate whether provider satisfaction was associated with adherence to instructions.
Methods: A 30-question online survey was distributed to 1,270 members of the International Society for Sexual Medicine (ISSM) from the EU, USA, Canada and Australia. Of the 30 questions, 10 survey questions had only one response consistent with the CCH package insert recommendations. An adherence score was calculated for each survey participant depending on how many of these questions were answered correctly. The average adherence scores of various groups were compared using a t-test. A chi-squared test was used to determine association between categorical variables.
Results: Of 202 total responses, 132 practitioners reported using CCH out of 1,270 ISSM members from countries where CCH is available (10.4% response rate). Practitioners from the USA had significantly better adherence scores than those outside the USA (average 7.7 vs 5.9, p < 0.001). Practitioners from outside the USA were more likely to be satisfied with CCH (p=0.006), and more experienced users (>20 uses) were more likely to be satisfied than less experienced users ( < 10 uses) (p=0.046). Satisfied users of CCH did not have significantly different adherence scores than non-satisfied users.
Conclusions: There appears to be wide variability in CCH practice patterns among the international urology community. Even though 67% of practitioners believed they followed the package insert guidelines, only 11% adhered to all the recommendations evaluated by the survey. More experienced users and practitioners outside the USA tended to be more satisfied with the product. Treatment adherence to package insert guidelines dose not appear to be associated with provider satisfaction.