Presentation Authors: Hatim Thaker, Chase Clemesha*, Mary K. Samplaski, Los Angeles, CA
Introduction: Many men take over-the-counter &[Prime]testosterone (T) boosting&[Prime] supplements in hopes of improving their T naturally. However, these claims may not be supported by evidence. We sought to evaluate the composition of &[Prime]T boosting&[Prime] supplements, their advertised claims, and compare this with the published literature.
Methods: 50 &[Prime]T booster&[Prime] supplements were evaluated for active ingredients and product claims. PubMed was reviewed for each component for any literature supporting the claims. We then reviewed the Recommended Daily Allowance (RDA) and upper tolerable intake level for each component.
Results: 90% of supplements claimed to &[Prime]boost T&[Prime], 50% &[Prime]improve libido&[Prime] and 48% to make men &[Prime]feel stronger&[Prime]. Other claims included &[Prime]building body mass&[Prime] (62%), &[Prime]increased energy&[Prime] (30%) and &[Prime]burn fat&[Prime] (28%). 111 components were found, with a mean number of 7.1 per product (range 18, median 7, mode 6, standard deviation 4.32). _x000D_
At PubMed search, 4 components had prospective data. Fenugreek and Shilajit: positive effect on T; D-Aspartic acid and Vitamin D: no effect on T. 4 components had non-prospective human data showing positive effect on T; 6 had animal data showing positive effect; 2 had non-prospective human data showing negative effect; 8 had animal data showing negative effect. 67 (60.4%) had no published data on their effect on T. _x000D_
27 supplements contained Fenugreek and/or Shilajit. 42 had components with non-prospective human data showing a positive effect on T; 42 had animal data showing a positive effect; 6 had non-prospective human data showing a negative effect; 21 had animal data showing a negative effect. One supplement had no components with human or animal data supporting a positive effect on T. _x000D_
For the 45 supplements that claimed to boost T, Table 1 lists the most common components, versus RDA. 2 supplements had over the upper tolerable intake of zinc.
Conclusions: 90% of &[Prime]T booster&[Prime] supplements claimed to boost T. However, only 12% of these had prospective human data to support these claims, based on their components. 48% contained components with data to suggest a negative effect on T. Many had supra-therapeutic doses of vitamins and minerals, occasionally over the upper tolerable limit, with associated risks. Patients need to know that &[Prime]T booster&[Prime] supplements may not contain components with mechanisms to support their claims.