Presentation Authors: Sung Han KIM, Mi Kyung Song, Bumsik Hong, Goyang, Korea, Republic of, Seok Ho Kang, Byong Chang Jeong, Ja Hyeon Ku, seoul, Korea, Republic of, Ho Kyung Seo*, Goyang, Korea, Republic of
Introduction: This study was aimed to propose a validated prediction model for disease-free survival (DFS) after radical nephroureterectomy (RNU) in a Korean population with upper urinary tract urothelial carcinoma (UTUC).
Methods: Retrospective review of 1561 cases of UTUC who underwent either open RNU (ONU, n = 906) or laparoscopic RNU (LNU, n = 615) from five tertiary Korean institutions between January 2000 and December 2012. Data were used to develop a prediction model using cox proportional hazards model. The prognostic factors were selected using the backward variable selection method. The prediction model performance was investigated by Harrellâ€™s concordance index (C-index) and Hosmer-Lemeshow type two statistics. Internal validation was performed by bootstrap approach, and National Cancer Center data set (n = 128) was used for external validation.
Results: A best-fitting prediction model with seven significant factors was developed. The C-index and two Hosmer-Lemeshow type statistics of the prediction model were 0.785 (95% CI, 0.755-0.815), 4.810 (p = 0.8506), and 5.285 (p = 0.8088). The optimism-corrected estimate through the internal validation was 0.774 (95% CI, 0.744-0.804) and the optimism-corrected calibration curve was close to the ideal line with mean absolute error = 0.012. In external validation, the discrimination was 0.657 (95% CI, 0.560-0.755) and two calibration statistics were 0.790 (p = 0.9397) and 3.103 (p = 0.5408), respectively.
Conclusions: A validated prediction model based on a large Korean RNU cohort was developed with acceptable performance to estimate DFS in patients with UTUC.
Source of Funding: a Korean National Cancer Center grant (NCC1810242-1).