Presentation Authors: Tina Schubert*, Wuerzburg, Germany, Kirk A. Keegan, Nashville, TN, Markus A. Kuczyk, Mario Kramer, Hannover, Germany, Oliver Patschan, Malmoe, Sweden, Allen Sim, Singapore, Singapore, Tokru Nakagawa, Tokyo, Japan, Daniel Joyce, Nashville, TN, Michael Drumm, Jason A. Efstathiou, Boston, MA, Hubert Kübler, Georgios Gakis, Würzburg, Germany
Introduction: There is a paucity of data regarding the predictive value of clinical staging on pathological outcomes in primary urethral carcinoma (PUC). Therefore, we aimed to analyse the concordance between clinical and pathological staging in an international cohort of patients without neoadjuvant treatment.
Methods: 75 patients diagnosed with PUC in 7 centers were included. Clinical staging was based on cross-sectional imaging. ROC analyses were conducted to analyze the predictive accuracy.
Results: Clinical tumor stage was cTa in 12 patients (16%), cTis in 11 (15%), cT1 in 23 (31%), cT2 in 15 (20%), cT3 in 10 (13%) and cT4 in 4 (5%). Pathological tumor staging was pTX in 7 patients (9%), pT0 in 1 (1%), pTa in 10 (13%), pTis in 9 (12%), pT1 in 13 (17%), pT2 in 17 (23%), pT3 in 11 (15%) and pT4 in 7 (9%). Clinical nodal stage was cN0 in 53 (71%), cN+ in 8 (11%) and cNX in 14 (19%). Among the 43 patients who underwent regional lymph node dissection, pathological nodal staging was pN0 in 34 (79%) and pN+ in 9 (21%). A high degree of concordance between clinical and pathologic tumor and nodal staging (ï‚³â‰¥cT2/cN+ vs.
Conclusions: While there is generally a high degree of concordance between clinical and pathological tumor and nodal staging, women with PUC exhibit significantly lower rates of concordance. This may be related to the lower resolution of the female urethral anatomy on cross-sectional imaging which demands improved imaging modalities for primary staging in women.