Presentation Authors: Stéphane Droupy*, Nîmes, France, Marie-Hélène Colson, Marseille, France, Nathalie Pello-Leprince-Ringuet, Valérie Perrot, Boulogne-Billancourt, France, Aurelien Descazeaud, Limoges, France
Introduction: The first few months of treatment for prostate cancer (PCa) are a difficult time for a couple. The degree of relational cohesion could have an effect on the experience of the disease. We analyzed the factors influencing the evolution of quality of life (QoL) in patients with PCa treated with hormone therapy for 6 months.
Methods: French prospective, multicenter, longitudinal and non-interventional study (NCT02630641). Urologists recruited partner-patient couples with PCa for whom hormone therapy was indicated. Data were collected at inclusion and after 6 months of treatment, on QoL (WHOQOL-BREF), perception of disease (B-IPQ), symptoms of the disease (QLQ-PR25) and perception of cohesion within the patient-partner relationship (dyadic adjustment, DAS-16). The results are presented as mean Â± standard deviation. The final analysis included 492 patients (74.2 years Â± 8.1), including 470 with a partner evaluation (70.5 Â± 9.0 years).
Results: Patient QoL remained mostly stable (0 Â±21.2), while patients' satisfaction with their health improved significantly (6.3 Â± 24.8, p < 0.001). The scores of physical (-1.4 Â± 14.5), psychological (-2.3 Â± 13.3) and social (-3.2 Â± 15.9) health were significantly degraded during the study. QoL was significantly deteriorated in patients who had good cohesion in the couple (-4.1Â±19.8) versus medium (2.8Â±19.8) or poor (1.6Â±22.5). A good cohesion in the couple seemed overall an unfavorable factor for the evolution of the scores of QoL, of health and of perception of environment. Associated factors in multivariate analysis with improvement in QoL were: initial presence of symptoms (OR [95% CI]: 3.0 [1.46, 6.17]) and initial low level (2.04 [1.12, 3.72]) or absence of sexual activity (2.23 [1.11, 4.50]).
Conclusions: The men who benefited the most from hormone therapy in terms of QoL were those who suffered from symptoms and those who had no sexual activity at baseline. The influence of the cohesion within the couple on the evolution of the QoL is not confirmed in multivariate analysis.
Source of Funding: Ipsen Pharma