Presentation Authors: Kyu Shik Kim*, Jae Hoon Chung, Seoul, Korea, Republic of, Tae Hyo Kim, Ki Soo Lee, Busan, Korea, Republic of, Cheol Young Oh, Seoul, Korea, Republic of, Joon Hwa Noh, Jun Seok Kim, Gwangju , Korea, Republic of, Won Tae Kim, Cheongju, Korea, Republic of, Seung Hwan Lee, Jae Heon Kim, Seoul, Korea, Republic of, Tae Nam Kim, Busan, Korea, Republic of, Wan Huh, Seung Wook Lee, Seoul, Korea, Republic of
Introduction: A thermo-sensitive anti-adhesive with a property of sol-gel transition was manufactured by a physical mixture of Poloxamer, Chitosan and Gelatin. Poloxamer-based thermo-sensitive sol-gel has been developed to reduce the incidence of postoperative adhesion formation. The purpose of this study was to evaluate the effect of poloxamer-based thermo-sensitive sol-gel instillation after transurethral resection of the prostate (TURP) on preventing urethral stricture.
Methods: A total of 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: Groups A and B. Patients in group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation, and patients in the group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of poloxamer-based thermo-sensitive sol-gel instillation was evaluated based on the International Prostate Symptom Score (IPSS)/Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), peak urine ï¬‚ow rate (Qmax), voided volume, postvoid residual volume (PVR) and cystoscopy.
Results: Among 198 initial participants, 80 patients in group A and 83 patients in group B had completed theexperiment. There were no significant difference in IPSS/QoL, and OAB-q. However, Qmax (mL/sec) showed significant difference between group A and group B (18.92Â±9.98 vs. 15.58Â±9.24, p=0.028) in 24 weeks after surgery. Also, result of PVR (mL) 24 weeks after surgery had significant difference between group A and group B (17.81Â±28.33 vs. 30.12Â±51.92 , p=0.061). By Cystoscopy, urethral stricture after TURP was seen in 2 of 80 subjects in group A and 10 of 83 subjects in group B (p=0.023).
Conclusions: Poloxamer-based thermo-sensitive sol-gel instillation after TURP decreased the incidence of urethral stricture.
Source of Funding: This study was sponsored by Daewoong Pharmaceutical Co LTD, Seoul,Korea.