Presentation Authors: Zade Roumayah*, Mustafa Deebajah, Marcus Jamil, James Peabody, Mani Menon, Shaheen Alanee, Detroit, MI
Introduction: Approximately 30% of prostatic adenocarcinoma (PCa) cases are attributed to hereditary causes. The National Comprehensive Cancer Network (NCCN) has published guidelines on genetic testing. The prevalence of the NCCN criteria for genetic testing in patients treated with surgery for high and intermediate risk PCa in not well characterized.
Methods: Patients with history of PCa treated with robotic surgery between January of 2016 and December of 2017 were identified from our well maintained intuitional database through an intuitional review board approved protocol. Only patients with available phone numbers and PCa Gleason score > 6 were included. A scripted phone call that operationalized NCCN criteria for testing into seven questions was used to contact patients. Prevalence of NCCN criteria in our patients&[prime] cohort was then quantified. Patient&[prime]s attitude towards tissue banking for study of genetic disease determinants was also examined.
Results: Of the 450 patients identified as candidates for the study, 227 (50.4%) patients responded to the study team&[prime]s phone calls. Average age of respondents was 64.6 years, 29.5% were African Americans, 21.3% had PCa > 7, 32.3% had positive family history for PCa, and 97.3% were health-insured. In individuals with family history of PCa, 28.8% had two family members affected, and 2.7% had three family members affected. Fathers were the most affected family members (55.7%), followed by brothers (22.7%). After scripted discussion with the patients, the prevalence of NCCN criteria for genetic testing was quantified and illustrated in table 1. During the same phone call, 31.5% of patients expressed agreement to have their samples acquired in the future into a tissue bank for research purposes into the genetic determinants of prostate cancer.
Conclusions: A recognizable percentage of post prostatectomy men with intermediate and high risk PCa fit the NCCN criteria for genetic testing, and genetic testing in this population is justified. Based on our data, there is a good interest among post prostatectomy men to contribute samples _x000D_
to research into inherited causes of prostate cancer.