Presentation Authors: Heather Carmichael, Aurora, CO, Granville Lloyd*, Denver, CO
Introduction: Benign prostatic hyperplasia with lower urinary tract symptoms (BPH/LUTS) is a disease with high prevalence, societal impact and cost. Our aim was to explore associations including marijuana usage, alcohol usage and other medical comorbidities with BPH/LUTS treatment.
Methods: We queried our hospital network database of nearly two million patients for data from the electronic medical record between January 2011 and October 2018. Men over the age of 40 who were on medical therapy for LUTS (selective alpha blockade and/or finasteride) were included. Patients with only one recorded visit or with a diagnosis of bladder/prostate malignancy were excluded. Medical therapy for LUTS was defined based on prescriptions for tamsulosin, alfuzosin and/or finasteride 5mg. Alcohol (AL) and marijuana (MJ) use were found from diagnosis code and/or social history text. Medical comorbidities including depression, obesity or metabolic syndrome (MetS), hypertension (HTN), erectile dysfunction (ED), hypogonadism, and diabetes (DM) were identified based on ICD-9/10 codes. Multivariable logistic regression was used to control for multiple additional confounders including patient age, race, insurance type, BMI, and vital signs. _x000D_
Alcohol (AL) and marijuana (MJ) use were found from diagnosis code and/or social history text. Medical diagnoses were based on ICD-9/10 codes. Multiple logistic regression was used to control for multiple confounders including patient age, race, insurance type, comorbidities, BMI, and vital signs.
Results: 173,469 patients were included; 20,548 (11.9%) were on medical treatment for LUTS. On univariable analysis, MJ use and ED were associated with increased risk of being on a LUTS medication. AL use was associated with decreased risk of being on a LUTS medication. _x000D_
On multivariable analysis, MJ remained associated with an increased risk of LUTS medication, as did ED and depression. AL use had no significant association with LUTS treatment. (TABLE)
Conclusions: Men with depression, marijuana usage, HTN, MetS, ED, hypogonadism and DM were more likely to be treated for LUTS, but alcohol use use was not associated. Marijuana use is a newly described association with LUTS and understanding of this interplay is desirable.
Source of Funding: Supported by the Health Data Compass Data Warehouse project (healthdatacompass.org)