Presentation Authors: Jean Wyman*, Haitao Chu, Minneapolis, MN, Yvette LaCoursiere, La Jolla, CA, Alayne Markland, Birmingham, AL, Elizabeth Mueller, Maywood, IL, Laura Simon, St. Louis, MO, Ann Stapleton, Palm Springs, CA, Carolyn Stoll, Siobhan Sutcliffe, St. Louis, MO, Jincheng Zhou, Minneapolis, MN, Tamara Bavendam, Bethesda, MD, Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, Minneapolis, MN
Introduction: Numerous studies have evaluated bladder function measurements in women with lower urinary tract symptoms, yet few have evaluated these same outcomes in healthy women. We conducted a systematic review and meta-analysis of non-invasive bladder function tests (diaries, ultrasonography, and uroflowmetry) to identify reference values in order to describe â€œnormalityâ€ in asymptomatic women.
Methods: A systematic search was conducted in 7 electronic databases from inception to February 2017, with handearching of reference lists. Observational studies with community-residing healthy women without lower urinary tract symptoms, urological disorders, progressive neurological diseases, renal disease, cancer, and catheter use were included. Pregnant and postpartum women were excluded. Two reviewers independently assessed studies for inclusion, extracted data, and evaluated quality. Discrepancies were resolved by a third reviewer. Outcomes included: urination frequencies, voided and postvoid residual volumes, and uroflowmetry values. Meta-analysis was performed using random-effects models to derive study-level pooled mean estimates and 95% confidence intervals, with heterogeneity assessed by I2 statistic.
Results: Thirty-six studies met inclusion criteria, with 22 studies (2488 women) included in the meta-analyses. Studies were conducted in 11 countries, with individual sample sizes varying from 14 to 352. Table 1 summarizes the results from meta-analyses. Insufficient data was available to estimate age group-specific values.
Conclusions: Insufficient data are available for defining normal bladder function in healthy women, with wide heterogeneity across studies. Further research is needed to determine normative reference values within age groups.
Source of Funding: National Institutes of Diabetes, Digestive, and Kidney Disorders, National Institutes of Health (DK106786, DK106853, DK106858, DK106898, DK106893. DK106827, DK106908, DK106892)