Presentation Authors: Blessan Sebastian*, Dhruv Sethi, Anna Nagle, Devina Thapa, Naomi Vinod, Zachary Cullingsworth, Andrea Balthazar, Adam Klausner, John Speich, Richmond, VA
Introduction: Currently, the only standard method to evaluate real-time bladder sensation during filling is an invasive urodynamic study. A sensation meter has been developed to track real-time changes in sensation and unique sensation event descriptors throughout filling. This meter has been used to characterize individuals with healthy bladders in earlier studies. The objective of this study was to test the hypothesis that real-time bladder sensation event descriptors are different in individuals with overactive bladder (OAB) compared to healthy individuals.
Methods: Participants completed an IRB-approved accelerated oral hydration protocol. Individuals with no urgency or high urgency were grouped based on ICIq-OAB surveys (question 5a=0 or â‰¥3). Participants consumed 2L Gatorade G2 and completed two consecutive fill-void cycles while using the tablet-based sensation meter to continuously record their bladder sensation on a 0-100% scale. A participant description for change in sensation, or &[Prime]sensation event,&[Prime] was recorded as &[Prime]tense,&[Prime] &[Prime]pressure,&[Prime] &[Prime]tingling,&[Prime] &[Prime]painful,&[Prime] and/or &[Prime]other.&[Prime]
Results: The study was completed by 12 non-OAB and 17 OAB participants. The rate of filling, based on durations and voided volumes, increased in Fill 2. In Fill 1, &[Prime]tingling&[Prime] occurred at a lower sensation levels in the OAB group (Fig 1, mean±standard error=64Â±3%) than the non-OAB group (77Â±3%, p=0.008). However, with faster filling in Fill 2, &[Prime]tingling&[Prime] in the non-OAB and OAB groups was not different (64±4% for both) and was not different from Fill 1 in the OAB group. In Fill 1, &[Prime]tense&[Prime] occurred at a lower sensation in the OAB group compared to the non-OAB group (78±3% vs 94Â±1%, p < 0.001) and &[Prime]pressure&[Prime] exhibited a similar trend.
Conclusions: OAB individuals experienced earlier &[Prime]tingling&[Prime] sensations regardless of fill rate. This indicates that fill rate may play a key role in the identification of sensation patterns. In addition, faster filling may cause healthy individuals to exhibit sensations such as &[Prime]tingling&[Prime] consistent with OAB behavior. The sensation meter enabled non-invasive characterization of sensation event descriptors, which may provide improved understanding of sensation in healthy individuals and those with OAB.
Source of Funding: This study was supported by NIH award R01DK101719 and VCU School of Medicine Dean&[prime]s Research Fellowship.