Presentation Authors: Helen Levey Bernie*, Carolyn A. Salter, Elizabeth A Schofield, Nicole Benfante, John P Mulhall, NY, NY
Introduction: Low testosterone (LT) is a known side effect of chemotherapy (CT) with well recognized sequelae. The T recovery rates after CT cessation are poorly defined. This study looked at T recovery after chemotherapy for varied cancers.
Methods: We reviewed men with a cancer diagnosis who received CT who had pre and post CT T levels drawn before noon, using LCMS, analyzed at a single lab. Low T was defined as total T < 300 ng/dL. T labs were classified in time segments relative to completion of CT as follows: pre-chemo, 0-3 months, 3-6m, 6-9m, 9-12m post, 12-15m, 15-18m, 18-24m, and 24+ months post-CT. For each time segment, we calculated mean T and percentage of labs that were within normal T range. Descriptive statistics as well as a Kaplan-Meier analysis of time to normal T level post-CT were performed.
Results: In our cohort, there were a total of 44 men with cancer who underwent CT with 85 post-chemo T levels. Mean age of the cohort was 41.3 years (Median = 33.5, STD = 18.5). Mean pre-CT total T (TT) level was 472Â± 247 ng/dl. 70% of these men had testicular cancer, 9% had bladder cancer and 20% had other. By 6 months post-CT, 64% of patients did not yet have a normal TT level. However, by the 2-year mark, only 35% of patients did not yet demonstrate recovery. Kaplan-Meier analysis of time to normal T can be seen in Fig 1.
Conclusions: In men with cancer who underwent chemotherapy, over 50% of men still do not have normal T levels post chemo at the 1 year post chemo timepoint. Our study shows the importance of following T levels in these patients post-chemo. Consideration should be given to offering testosterone therapy to those patients with LT.