Presentation Authors: Sun Tae Ahn*, Dong Hyun Lee, Hyeong Guk Jeong, Sang Woo Kim, Jong Wook Kim, Du Geon Moon, Seoul, Korea, Republic of
Introduction: In elderly, age-related changes in sleep depth and continuity affect normal circadian rhythm and the normal circadian pattern of micturition as well. Although it seems logical that use hypnotics for improving sleep quality and desmopressin for decreasing nocturnal urine output, they increase the potential risk of dependency and side effects in elderly. Thus we herein investigated the efficacy and safety of melatonin, an antioxidant and sleep inducer free of addiction, on treatment of nocturia in elderly patients as a pilot study.
Methods: The study was conducted prospectively and enrolled male patients over 55 years old who had two or more episode of nocturia per night. Melatonin 2mg (CircadinÂ®) was administered orally 2-3 hours before bedtime for 12 weeks. All patients were assessed the Pittsburgh Sleep Quality Index (PSQI) and frequency volume (FV) chart at baseline and 12 weeks after starting melatonin.
Results: Overall, 50 patients were completed the study. Total of 30 of them (60%) showed poor sleep quality (SQ) defined as a score of 6 or more on the PSQI global score at baseline. In this group global PSQI score significantly improved (from 10.5Â±2.9 to 7.2Â±4.0, p=0.01) whereas 20 patients (40%) with good SQ did not (from 3.3Â±1.4 to 4.4Â±2.9, p=0.198). The number of nocturia episodes significantly decreased in poor SQ group and superior to good SQ group. (Figure. 1) Changes of other FV chart values in patient with poor SQ group and good SQ group were presented in Table 1. Three patients had dizziness; the remaining patients had no adverse drug-related events.
Conclusions: Melatonin improved nocturia in elderly men with sleep disorder and provided better adverse effect profile than drugs currently used for the treatment of nocturia. Therefore it merits consideration for further clinical trials.