Presentation Authors: Robert Geraghty, Sarah Prattley*, Abdihakim Maalim, Bhaskar Somani, Paul Cook, Paul Roderick, Southampton, United Kingdom
Introduction: Examination of association between chronic hyperglycaemia, in the form of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in the context of metabolic syndrome (MetS), and the risk of kidney stone disease (KSD)
Methods: P-Chronic hyperglycaemic (DM and IGT)Câ€“Without hyperglycaemiaOâ€“KSDSâ€“Systematic review and meta-analysis of published observational studies (cohort, case control and cross-sectional) using PRISMA guidelines for studies reporting on DM or MetS and KSD. English language articles from January 2001-June 2018 reporting on all observational studies. Studies were excluded if there was no comparator group or fewer than 100 patients. Both unadjusted and adjusted (where reported) values were identified and used for meta-analysis. Risk is presented as RR for cohorts and OR for case-control and cross-sectional studies. Bias was assessed using the Newcastle-Ottawa quality assessment scale. PROSPERO registration number CRD42018093382.
Results: 2340 articles were screened with 13 studies included for meta-analysis, 7 DM (3 cohort, 3 cross-sectional*, 3 case-control) and 6 MetS (all cross-sectional), with 5 providing data on IGT alone. These included 28,329 patients with DM, 31,767 patients with MetS and 12,770 with IGT. Controls included; DM: 589,791 patients, MetS: 178,050 patients and IGT: 293,852 patients. Adjusted risk for DM cohort studies was RR=1.23 (0.94-1.51) (p < 0.001) (see fig. 1), for DM cross-sectional/case-control studies were OR=1.32 (1.21-1.43) (p < 0.001), for IGT cross-sectional studies was OR=1.26 (0.92-1.58) (p < 0.001) (see fig. 2) and MetS cross-sectional studies was OR=1.35 (1.16-1.54) (p < 0.001). Risk of bias was moderate.
Conclusions: Chronic hyperglycaemia increases the risk of developing kidney stone disease. In the context of the diabetes pandemic, this increases the risk of stone related morbidity and mortality.