The University of Massachusetts Boston
I am currently the Alton J. Brann Endowed Chair and Distinguished Professor of Science and Mathematics at the University of Massachusetts Boston. I am the Co-PI of the University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research, and am the Director of the newly established Center for Personalized Cancer Therapy, a joint venture between the Dana-Farber/Harvard Cancer Center and the University of Massachusetts Boston. A scientific focus of the center is to elucidate how lifestyle choices, particularly those that promote diet-induced obesity and type 2 diabetes mellitus (‘diabesity’), modulate the tumor microenvironment, and how such modulation affects tumor initiation, progression, and response to therapy and may contribute to cancer disparities in different populations. I have led peer-reviewed and funded research for the past 20 years focused on elucidating the molecular genetic alterations and dysfunctional inter- and intra-cellular signaling mechanisms that promote urinary tract (kidney, bladder, prostate) pathobiology. Research in the Macoska laboratory is currently focused on: 1) Defining the mechanisms through which dysfunctional paracrine interactions between diverse cell types – epithelial, fibroblastic, endothelial, leukocytic – develop consequent to aging or infection, and how these dysfunctional interactions contribute to the development of benign and malignant disease; 2) Elucidating the intracellular mechanisms through which inflammatory cytokines, particularly CXC-type chemokines, secreted by aging stromal fibroblasts and inflammatory cells stimulate cellular proliferation and myofibroblast phenoconversion, and the association of these pathobiologies, particularly tissue fibrosis, with organ dysfunction and malignancy, and 3) Translating laboratory-based knowledge to the development of clinically efficacious biomarkers and therapeutics.
Sunday, May 5
9:30 AM – 9:50 AM