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C1. Clinical trials (abstracts submitted to C1 should choose a secondary category that describes the subject matter of the trial)
Oral Abstract Submission
Ann E. Woolley, MD, MPH
Attending Physician
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
Hilary J. Goldberg, MD, MPH
Attending Physician
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
Steve K. Singh, MD, MSc
Attending Surgeon
University of Toronto
Toronto, ON, Canada
Disclosure: Nothing to disclose
Mandeep R. Mehra, MD
Attending Physician
Brigham and Women's Hospital
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
Michael M. Givertz, MD
Attending Physician
Brigham and Women's Hospital
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
Antonio Coppolino, MD
Attending Surgeon
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
Vivien Cheng, BA
Research Coordinator
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
John Fanikos, RPh, MBA
Director of Pharmacy
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
David P. Harrington, PhD
Professor of Biostatistics and Statistics
Harvard University
Boston, MA
Disclosure: Nothing to disclose
Hari R. Mallidi, MD
Attending Surgeon
Brigham and Women's Hospital
Boston, MA
Disclosure: Nothing to disclose
Lindsey R. Baden, MD, MSc
Attending Physician
Brigham and Women's Hospital
Boston, Massachusetts
Disclosure: Nothing to disclose
Background :
The DONATE HCV Trial demonstrated that hearts and lungs can be safely transplanted from HCV-infected donors using a shortened, 4-week, pre-emptive course of direct acting antivirals (DAA). The 6-month results from that study of 35 patients are encouraging but longer-term data from a larger cohort are needed to better define the risk-benefit profile.
Methods :
We conducted a single-center trial to transplant thoracic organs from HCV viremic donors, irrespective of HCV genotype, to HCV-uninfected adults. Sofosbuvir/velpatasvir, a pan-genotypic DAA, was pre-emptively administered for 4 weeks, beginning within hours of transplant. The primary outcome was a composite of HCV clearance and graft survival at 6 months post-transplant. Secondary outcomes included graft survival and mortality at 12 months and the occurrence of grade 3 or higher adverse events (AEs). This protocol is IRB approved and all participants provided written informed consent. (NCT03086044).
Results :
Between March 2017 and March 2019, 57 participants were enrolled: 46 received lung and 11 received heart transplants. The median donor HCV viral load (VL) was 889,817 IU/mL (IQR 212,062 – 4,641,078). 53 of 57 (93%) recipients had detectable HCV VL immediately after transplant, with median VL of 1,460 IU/mL (IQR 463 – 6,618). HCV VL became negative by about 2 weeks and subsequently remained undetectable in all participants. 49 of 49 (100%) and 34 of 35 (97%) participants were alive with excellent graft function and an undetectable HCV VL at 6 months and 1-year post-transplant, respectively. No treatment-related serious AEs were identified. Outcomes between transplant recipients from HCV donors vs. non-HCV donors were similar, including the occurrence of renal failure, respiratory failure, and non-HCV infections.
Conclusion :
In patients who received thoracic organs from HCV viremic donors, a 4-week antiviral treatment course initiated within hours of transplant prevented the establishment of HCV infection. These data demonstrate that thoracic organs from HCV viremic donors can be transplanted safely with excellent graft and recipient survival at 12 months with a similar AE profile compared to transplant recipients who received thoracic organs from non-HCV donors. 2-year outcomes will be available October 2019.