Monday Roundtable Luncheon
Arkansas ranks fifth in the nation for HPV-associated cancer incidence. This study assesses the trends of HPV-associated cancer by anatomical site, sex, race, and age in Arkansas from 2001-2015. Analysis was conducted using the National Program for Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) U.S. Cancer Statistics Database. HPV-associated cancers were defined as invasive malignancies of sites in which HPV DNA is commonly found (cervical carcinomas, and squamous cell carcinomas (SCC) of the oropharynx, rectum, anus, penis, vagina, vulva) and confirmed microscopically. Trends, characterized by average annual percent change (AAPC), in rates were calculated using joinpoint analysis and considered to increase or decrease at p<0.05. SEER*Stat software (v 8.3.5) was used for all analyses. In Arkansas, a total of 6,248 new cases of HPV-associated cancer were reported during 2001-2015. Oropharyngeal SCC was the most common cancer (2,458 cases). Rates increased annually (p<0.05) for oropharyngeal (3.0%) and anal (2.7%) SCC among males and females and vulvar SCC (2.3%) among females. By 2015, oropharyngeal SCC rates in males (9.9 per 100,000) surpassed cervical carcinoma rates in females (9.8 per 100,000). During 2011-2015 oropharyngeal SCC rates were higher in males (9.3 per 100,000) than females (2.2 per 100,000). Males ages 60-69 had the highest rate (29.4 per 100,000) of oropharyngeal SCC from 2011-2015. During 2001-2015 HPV vaccination could have prevented 4,600 cancers. Dentists are being urged to provide HPV vaccine prescriptions to unvaccinated patients.