Formulation and Quality – Chemical
2019 PharmSci 360
The routine manufacturing of oral dosage forms as tablets and capsules is outdated and does not provide dosage flexibility for children, swallowability for approximately 50% of the US population, or taste masking. At-home reformulation of these dosage forms is a common practice, despite resultant lack of dosing accuracy and potential caregiver contact with toxins and teratogens. Newer technologies such as 3D printing and manufacture of minitablets, to allow dose optimization, exist and should be more widely applied to enable dose accuracy and patient compliance.