Quick Fire Session
SCMR 22nd Annual Scientific Sessions
Light-to-moderate alcohol consumption is associated with lower pulse wave velocity, particularly in Japanese women1. However, there is currently limited data on its association with aortic distensibility (AoD), a cardiovascular magnetic resonance (CMR) imaging measure of arterial stiffness. We therefore examined the association between alcohol consumption and AoD in a middle-aged population in UK Biobank.
AoD in the ascending (AA) and descending aorta (DA) were derived from maximal and minimal areas using semi-automated methods from transverse bSSFP cine images of 4,996 participants in the UK Biobank cohort. Weekly alcohol consumption was calculated based on self-reported questionnaires where participants reported the amount and type of alcohol consumed in an average week or month. These data were used to convert into total units of alcohol consumed per week.
Alcohol consumption was divided into 3 groups – (1) non-drinkers, (2) those who drink within current UK guidance of ≤14 units/week2, (3) alcohol intake >14 units/week. Associations between these groups and AoD were assessed for men and women separately. Multivariate regression models were performed and adjusted for age, sex, ethnicity, Townsend deprivation index, smoking, higher levels of education, BMI, systolic blood pressure, diastolic blood pressure, resting heart rate, presence of diabetes, hypertension and hypercholesterolaemia. The ≤14 units/week group was used as the reference category of alcohol consumption in our models.
2074 male (mean age 63±7.5) and 2196 female (mean age 61±7.4) participants were included in the final analyses (Table 1). The mean AoD was highest in those who drink <14 units/weeks apart from AA AoD in men where non-drinkers have the highest mean value though it was only marginally higher than those drinking <14 units/week (1.75 x 10-3 mmHg-1 vs 1.74 x10-3 mmHg-1).
The findings of our regression models by sex are shown in Table 2. In men, both non-drinkers and those who drink above guidance levels did not have significantly different AoD values compared with our reference group. However, in women, AoD were significant lower in those who drink more than 14 units/week compared with those drinking <14 units/week (effect estimates -5.74% for AA AoD and -3.61% for DA AoD respectively). No statistical difference in AoD is seen between non-drinkers and those who drink <14 units/week.
In our studied population, alcohol consumption above current UK guidance is associated with increased aortic stiffness in both ascending and descending aorta. However, these effects are only seen in females. We found no difference in aortic stiffness measures between non-drinkers and those who drink within guidance levels for both men and women.