Taha Qazi, MD1, Alexander J. Smith, BS2, Megan Alexander, BSc2, Eric Jones, BSc3, Janice Weinberg, ScD3, David Hammer, MD4, Ting Wu, MD5, Ansu Noronha5, Francis A. Farraye, MD, MSc6
1Boston University Medical Center, Brookline, MA; 2Boston University School of Medicine, Boston, MA; 3Boston University School of Public Health, Boston, MA; 4Boston University Medical Center, Boston, MA; 5Boston Medical Center, Boston, MA; 6Mayo Clinic, Jacksonville, FL
Introduction: Inflammatory Bowel Disease (IBD) is associated with a reduced quality of life, including a high incidence of poor sleep. Minority patients with IBD describe poorer subjective symptoms of disease. Minority patients are more likely to report poorer sleep quality compared to Caucasian patients. There are limited data on the assessment of sleep in minority patients with IBD. In this prospective cohort study, we aim to compare objective sleep parameters assessed by wrist actigraphy in minority IBD patients compared to Caucasian IBD patients.
Methods: 73 patients with a diagnosis of IBD were recruited to take part in this IRB approved study. Subjects were stratified into two cohorts by self-identification: minority subjects (Blacks and Non-Black Hispanic subjects) and Caucasian, non-minority individuals. Subjects were excluded based on significant co-morbidity, a history of a sleep disorder, or demographics which did not fit into categorized cohorts. Subjects completed sleep surveys and were provided with an accelerometer that estimated sleep patterns. Comparisons of actigraphic parameters were performed between minority and non-minority cohorts. Regression analyses were performed to determine whether minority status was independently associated with poorer sleep parameters assessed by actigraphy. Predictors that were found to be different by < 0.1 between cohorts were included in the models.
Results: Of the recruited subjects, 64 subjects completed 3 days of actigraphy data. 33 subjects were minority patients and 31 individuals were non-minority patients. The demographics of the cohorts are provided in Table 1. Table 2 details the univariate analyses. A higher proportion of minority patients had poorer sleep efficiency (SE) and fragmented sleep compared to Caucasian patients (90.9% vs. 67.7%, p=0.03 and 87.8% vs. 61.3%, p=0.02). Minority status was independently associated with both poor SE (OR: 6.41 CI: 1.48-28.17, p=0.0139) and fragmented sleep (OR: 4.98, CI: 1.09-22.89, p=0.0389), (Tables 3.0A and 3.0B.)
Discussion: In our study minority subjects were found to have poorer objective measures of sleep assessed by actigraphy compared to non-minority subjects. Culturally relevant care addressing psychosocial issues, including sleep are important in the care of minority patients with IBD. Further studies investigating the role of sleep in diverse populations with IBD are warranted to determine the etiologies of poor sleep in these patients.
Citation: Taha Qazi, MD; Alexander J. Smith, BS; Megan Alexander, BSc; Eric Jones, BSc; Janice Weinberg, ScD; David Hammer, MD; Ting Wu, MD; Ansu Noronha; Francis A. Farraye, MD, MSc. P2295 - DISPARITIES IN OBJECTIVE SLEEP QUALITY AS ASSESSED BY WRIST ACTIGRAPHY IN MINORITY PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Program No. P2295. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.