Category: Neurodegenerative Disease (e.g. MS, Parkinson's disease); Brain Injury; International
To evaluate the mechanisms for restoring selective attention, it is advisable to study the network pattern of intercortical interaction with formation of executive cognitive functions of cluster's based on auditory evoked potentials (AEPs) mapping and positron emission tomography (PET-scan).
Design : Two groups of patients with Parkinson's disease with different levels of cognitive impairment, as well as a group of neurological patients without cognitive impairment were formed.
Setting : AEPs mapping for extracting relevant signals from deviant PET-scan with fluorodeoxyglucose was performed. The rate of glucose metabolism in different parts of the brain was determined.
Participants (or Animals, Specimens, Cadavers) : 103 Parkinson's disease patients with neurologic attention deficit disorder were examined. 26 healthy persons made up a control group.
Interventions : Not applicable.
Main Outcome Measure(s) :
The recovery dynamics of the early mechanisms of selective attention according to the data of short AEPs components was estimated. The dynamics of the recovery of late selective attention mechanisms was estimated according to the intercortical interaction of the fields of PET-scan and long AEPs components.
Results : PET-scan without the syndrome of executive cognitive impairment established the 4-factor's structure of the attention system: dorsal (selective attention), ventral (involuntary attention), operative rest and visual attention system. The same factor structure in the control group of healthy young persons was recorded.
The reduction of amplitude of the AEP components with peak latency 15-40 ms with target signals indicates the inverse effect of brain cortex regions to brainstem in early mechanisms of selective attention. The amplitude of the P90 AEP component is significantly higher in the absence of a relevant signal. The late positive waves with peak latency 250-350 ms in the target task are reduced.
The dynamics of the restoration of selective attention with the registration of AEPs and PET- scan allows to simulate the prognosis of cognitive impairment in Parkinson's disease.
Sergey Lytaev– Physiology Department, Head, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Saint Petersburg City
Mikhail Aleksandrov– Clinical Neurophysiology Department, Head, Almazov National Medical Research Centre, Saint Petersburg, Saint Petersburg City
Mikhail Lytaev– PhD student, The Bonch-Bruevich Saint - Petersburg State University of Telecommunications, Saint Petersburg, Saint Petersburg City
Daniil Susin– The Researcher, Bekhtereva Human Brain Institute, Saint Petersburg, Saint Petersburg City