Category: Technology (e.g. robotics, assistive technology, mHealth); Cross-Cutting
Objective : To develop the gastrointestinal digital twin for rehabilitation of functional dyspepsia in spinal cord injury (SCI) patients: A pilot study
Design : As a preliminary study for developing the gastrointestinal digital twin for rehabilitation of functional dyspepsia in SCI patients, this study provided the novel electrode system to measure the biomechanical properties (smooth muscle contractility) through endoscopy and developed the abdominal finite element model containing gastrointestinal tract.
Setting : Animal laboratory
Participants (or Animals, Specimens, Cadavers) : Specimens of porcine gastric tissues and anesthetized pigs about three months old
Interventions : Not applicable
Main Outcome Measure(s) : The smooth muscle contraction force in the principal direction by electrical stimulation was measured in vitro (specimen) and in vivo (anesthetized pigs) condition. The measured data were then applied to the finite element model to confirm the contraction behavior.
Results : The smooth muscle contraction forces from the greater curvature of the middle third of the porcine stomach body were 0.603 N in the XX direction, 0.112 N in the XY direction, and -0.075 N in the YY direction respectively. The frequency of the peristaltic motion of the gastrointestinal finite element model was about 11.5 cycle per minute (cpm).
The contractility of gastrointestinal muscles measured in this study is expected to be useful in identifying the mechanism of gastrointestinal contraction behavior. In the following study, real-time data communication between the gastrointestinal finite element model developed in this study and the Internet of Things (IoT) based abdominal surface EGG sensor will be implemented.