Category: Stroke; Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development)
Objective : To compare the effectiveness of Continuous Training (CT), Interval Training (IT) and Combination of Continuous and Interval Training (ComCIT) modes of aerobic exercise on selected biochemical variables of Stroke Survivors (SS).
Design : Intervention studies: randomized controlled trial
Setting : University of Port Harcourt Teachng Hospital, Port Harcourt, Nigeria
Participants (or Animals, Specimens, Cadavers) : Sixty-nine consecutively recruited stroke survivors (36 females; 33 males) participated in this trial. They were randomly assigned into one of CT (n=21), IT (n=25), and ComCIT (n=23) groups
Interventions : All the participants underwent aerobic training at 40–70% of heart rate reserve using bicycle ergometer for eight consecutive weeks following the American Heart Association/American Stroke Association recommendation
Main Outcome Measure(s) : Biochemical variables such as Total Cholesterol (TC), Low-Density Lipoprotein (LDL), Very Low-Density Lipoprotein (VLDL), High-Density Lipoprotein (HDL), creatinine and Fasting Blood Glucose (FBG) were determined using AUDICOM AC 9900 Analyser
Results : Participants in the CT (61.48±6.79 years), IT (58.60±10.15 years) and ComCIT (58.17±8.80 years) were comparable in age. No significant difference was observed in all the baseline variables across the three groups (p>0.05). Post-intervention TC (4.97±0.44; 4.56±0.52; 3.95±0.46) (F=31.738, p<0.001) and VLDL (0.70±0.19, 0.81±0.11, 0.52±0.17) (F=36.817, p<0.001) were significantly lower in the ComCIT group while HDL (0.96±0.19; 1.05±0.14; 1.05±0.19) (F=4.931, p=0.016) was higher in the ComCIT and IT than in the CT group. However, post-intervention FBG (4.85±0.76; 4.21±0.82; 4.61±0.79) was significantly lower in the IT group than the other groups.
The combination of continuous and interval aerobic training is the most effective mode for improving biochemical variables of stroke survivors with the exception of fasting blood glucose.