Category: Measurement; Neurodegenerative Disease (e.g. MS, Parkinson's disease)
Objective : To determine the internal consistency and test-retest reliability of objective and subjective measures of prospective memory in people with Parkinson disease-related mild cognitive impairment (PD-MCI) in preparation for a clinical trial of prospective memory training
Design : Cohort study with baseline, 1 month and 3 month measurement time points
Setting : Academic medical center
Participants (or Animals, Specimens, Cadavers) : 15 volunteers with PD-MCI (M [SD] age = 64.9 [7.3], Hoehn & Yahr = 2 [0.4]; 80% college graduate; 47% male; 100% white)
Interventions : Not applicable
Main Outcome Measure(s) : The Virtual Week (VW), a computerized test that mimics real-world prospective memory challenges, was the objective measure of laboratory-based prospective memory performance. The self-report Prospective and Retrospective Memory Questionnaire (PRMQ) was the subjective measure of everyday prospective memory function. To match the design of the planned intervention trial, the VW was administered at baseline and 1 month follow-up and the PRMQ was administered at baseline, 1 month, and 3 months follow-up. Cronbach’s alpha (α) assessed internal consistency and intraclass correlation coefficients (ICC; mean rating, absolute agreement, 2-way mixed effects model) assessed test-retest reliability.
Results : The VW had good to excellent internal consistency (α = 0.78-0.85) and excellent test-retest reliability (ICC = 0.82-0.83). The PRMQ had good to excellent internal consistency (α = 0.79-0.85) and excellent test-retest reliability (ICC = 0.81-0.92).
Conclusions : Our prior work showed that the VW and PRMQ are sensitive to prospective memory strategy training in non-demented people with PD. These data further support their construct validity and reliability among people with PD-MCI. Importantly, these measures demonstrate stability over time in the absence of intervention, which supports their potential utility as outcome measures in clinical trials of prospective memory interventions.
Erin Foster– Assistant Professor, Washington University School of Medicine, St.Louis, Missouri
Tiffany Nguyen– Occupational Therapy Doctoral student, Washington University School of Medicine, St. Louis, Missouri
Tasha Doty– Research Assistant, Washington University School of Medicine, St. Louis, Missouri
Ruth George– Occupational Therapy student, Washington University School of Medicine, St. Louis, Missouri