Category: International; Geriatric Rehabilitation
To investigate cognitive decline and potential risk factors in a subgroup of individuals who presented with cognitive decline at 5-years post baseline.
Design : Participants underwent a comprehensive neuropsychological assessment of neurocognitive measures of auditory and visual working memory, long term memory, executive functioning, naming abilities, and general cognitive performance. In addition, participants completed blood and genetic testing (APOE e4) and a series of questionnaires measuring quality of life and psychosocial functioning. Data collected from both the baseline and the third wave assessment (at 5 years post initial assessment) were included.
Setting : General community
Participants (or Animals, Specimens, Cadavers) :
Out of the 786 participants in the NEUROAGE project, 135 participants were followed through the third wave. A subgroup of 11 participants presenting with significant cognitive decline were analyzed with a mean age of 75.3 (SD = 5.23) and 6 years educational level.
Interventions : Not applicable
Main Outcome Measure(s) : Executive Functions, Verbal Memory, Naming Abilities
Results : As a group, the 135 participants did not demonstrate significant cognitive changes in the executive functions and verbal memory domains (MANOVA >.05). The 11 participants who showed significant decline demonstrated change in multiple cognitive domains including episodic memory and executive functioning. Qualitative analyses revealed that 7 out of these 11 participants, reported subjective cognitive decline at baseline; all reported subjective vision problems and 3 subjective hearing problems at baseline. Five were presented with increased glucose levels, 6 with high cholesterol and 3 were APOEε4 positive
Conclusions : 8.5% of the initial sample presented with a cognitive decline at five years post baseline. Subjective cognitive, vision and hearing problems at baseline as well as genetic and cardiovascular risk factors also may relate to subsequent cognitive decline in otherwise cognitively healthy adults, suggestive of the need for careful monitoring
Antreas Chadjikyprianou– Special Scientist, Center for Applied Neuroscience, PhD Student of Clinical Psychology, Center for Applied Neuroscience, University of Cyprus, Larnaca, Larnaca
Fofi Constantinidou– Professor of Language Disorders and Clinical Neuropsychology, University of Cyprus, Nicosia, Nicosia