Category: Brain Injury; Neuroplasticity (includes neuroscience); Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development)
To provide preliminary data on neural changes that can be related to cognitive and functional outcome measures in chronic patients with moderate to severe traumatic brain injury (TBI), using a multi-modal approach.
Prospective longitudinal study
Casa Colina Hospital and Centers for Healthcare Research Institute (Pomona, CA).
Participants (or Animals, Specimens, Cadavers) :
Eight TBI patients (7 males; age range: 21-44 years old; 12-22months post-injury; 5 severe TBI) were included in this study
Main Outcome Measure(s) :
The following data were collected at monthly intervals over 6 months: a) Blood sample to detect changes in molecular blood-based biomarkers such as neuron-specific enolase (NSE), glial fibrillary acid protein (GFAP), S-100β protein, tau protein (C-tau). Blood-based biomarkers are determined using ELISA. b) Magnetic Resonance Imaging (MRI) recordings were performed on a Siemens Magnetom Verio 3T to assess structural changes. MRI data are analyzed in collaboration with the UCLA Department of Psychology, using FMRIB Software Library (FSL). c) Electrophysiological recordings. using a B-Alert wireless system, changes in electrical activity and processing were recorded during 5 minutes resting state. EEG analyses were performed using EEGLAB. D) Neuropsychological assessments were performed by trained clinicians to assess cognition and functional recovery.
Using mixed model analyses, trend of changes were observed in (right) hippocampus and were related to NSE, tetha activity and changes in cognitive status across time.
Our preliminary findings suggest changes of neural activity and brain plasticty that can occur even in a short time window in chronic TBI. Changes related to the hippocampus should be investigated further particularly regarding its link to chronic traumatic encephalopathy (CTE).
Caroline Schnakers– Assistant Director, Research Institute, Casa Colina Hospitals and Centers for Healthcare, Pomona, California
Micah Johnson– Graduate researcher, UCLA, Los Angeles, California
Evan Luktenhoff– Post doctoral fellow, UCLA, Los Angeles, California
Martin Monti– Professor, UCLA, Los Angeles, California
David Patterson– Physical Medicine & Rehabilitation Doctor, Casa Colina hospital and Centers for Healthcare, Pomona, California
Gary Jensen– Radiologist Doctor, Casa Colina hospital and Centers for Healthcare, Los Angeles, California
Emily Rosario– Director of the Research Institute, Casa Colina hospital and Centers for Healthcare, Los Angeles, California