Category: Neuroplasticity (includes neuroscience); Arts & Neuroscience; Stroke
Objective : To identify differences in structural and functional brain connectivity between post-stroke mild and severe motor impairment.
Retrospective cross sectional study
Twenty-four chronic stroke patients, who underwent diffusion tensor imaging and resting state functional MRI, were included. All patients were classified into two groups(mild motor impairment: 11 patients; and severe motor impairment: 13 patients) according to their Fugl-Meyer motor assessment score.
Participants (or Animals, Specimens, Cadavers) : With randomized selection, we included twenty-four chronic stroke patients.
Interventions: Not applicable.
Main Outcome Measure(s) :
tract-based spatial statistics and groupindependent component analysis were applied to investigate between-groupdifferences in structural and functional connectivity, respectively.
The structural connectivity within motor-related brain regions was significantly increased in mild motor impairment than that in severe motor impairment (corrected P< 0.05). The intra-network functional connectivity between: 1. supplementary motor area and primary motor cortex in the affected hemisphere, 2. supplementary motor area and dorsolateral prefrontal cortex in the unaffected hemisphere and 3. ischemic lesion and primary motor cortex in the unaffected hemisphere was significantly increased in mild motor impairment than that in severe motor impairment (PFWE< 0.05).
A better motor recovery after stroke could be facilitated by means of treatments aimed at enhancing structural and functional connectivity among motor related brain regions.