Category: Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development); Neuroplasticity (includes neuroscience)
Objective : Determine iwhther differences exist between in a group of Multiple Organ Dysfunction Syndrome (MODS) and healthy-control in neuroimaging and neuropsychological functioning
Design : Cross sectional study.
Setting : Participants were recruited at Cruces University Hospital (Bilbao, Spain).
Participants (or Animals, Specimens, Cadavers) :
We compared two groups (matched by age, sex and years of education): N1 = 13 MODS patients with NABD evaluated at 6 months after ICU discharge, and N2 = 13 healthy controls.
Interventions : Not applicable
Main Outcome Measure(s) : Two main outcome were analyzed: brain magnetic resonance imaging outcome (structural, diffusion tensor and functional at rest), and a neuropsychological battery, including cognitive and emotional measures.
As compared to control, MODS patients showed no significant in structural imaging, neither diffusion tensor imaging nor neuropsychological scores. However, we found significantly worsement in quality of life together with an increment of the functional connectivity (FC). In particular, we found that the default mode network (DMN) hyperconnects (increasing the node strength of the FC matrix) to three classes of networks: primary sensory (such as auditory, sensory-motor and visual), multimodal integration (such as dorsal attention and salience) and higher order cognition networks (such as fronto-parietal, language and executive control).
The statistical significant hyperconnectivity found in the DMN (occurring when no significant differences in the neuropsychological performance existed) indicates that the functional brain alterations might anticipate to the neuropsychological outcome in MODS. Although these patients do not have an apparent structural damage after MODS, nor yet a significant neuropsychological impairment, they have network alterations at the functional level of DMN hyperconnectivity, that similar to what happens at the onset of other pathologies, might indicate a possible mechanism for brain compensation occurring after MODS.
Juan Carlos Arango-Lasprilla– Ikerbasque Research Professor, Ikerbasque; Biocruces Vizcaya Health Research Institute, Barakaldo, Pais Vasco
Antonio Jiménez-Marín– PhD Student, Biocruces Bizkaia Research Health Institute, Barakaldo, Pais Vasco
Diego Rivera– Professor & Researcher, Universidad Pública de Navarra, Pamplona, Navarra
Ibai Diez– Researcher, Functional Neurology Research Group, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, Barakaldo, Pais Vasco
Fermin Labayen– Medical Doctor, Cruces University Hospital, Barakaldo, Pais Vasco
Irati Garrido– Medical doctor, Biocruces Bizkaia Research Health Institute, Barakaldo, Pais Vasco
Daniela Ramos-Usuga– Student, Unibersitat Oberta de Catalunya, Barakaldo, Pais Vasco
Javier Rasero– Researcher, Biocruces Bizkaia Research Health Institute, Barakaldo, Pais Vasco
Alberto Cabrera– Medical doctor, Osatek, Galdakao, Pais Vasco
Jesus M. Cortes– Research professor, Biocruces Bizkaia Research Health Institute, Barakaldo, Pais Vasco