Category: Brain Injury; Health Services Research
Alzheimer's disease has become a major social problem due to the aging population in some developed countries, including Japan. In this study, we investigated the relationship between physical activity, amyloid β, attention, and memory in the elderly women.
This is a cross-sectional study.
We advertised in the local newspaper to recruit older adults to participate in this study.
Participants (or Animals, Specimens, Cadavers) : The subjects were 79 elderly women (72.3 ± 4.7, aged 65-83 years).
Interventions : Not applicable.
Main Outcome Measure(s) : Physical Activity Scale for the Elderly (PASE) was used to evaluate the physical activity of the subjects. Blood (plasma) amyloid β 42 (Aβ; a cognitive function marker) was determined as the primary outcome. Among the five cognitive tests, we assessed five points in “attention” and “memory” performance items.The characteristics of the three groups (active (AG), moderate (MG), and inactive physical activity (IG)) were compared using the one-way analysis of variance (ANOVA), while Bonferroni's method was used for the post-hoc tests.
The result of the amount for Aβ in ANOVA showed a significant difference in each group (P
Although the cognitive performance tests in “attention” and “memory” items were no significant relationship with the groups, Aβ showed a remarkable significant difference between the groups. It indicates that Aβ deeply depends on physical activity. We conclude that high-intensity physical activity could lead to prevent cognitive decline.
Jieun Yoon– Researcher, University of Tsukuba, Tsukuba, Ibaraki
Kazunori Sasaki– Assistant Professor, University of Tsukuba, Tsukuba, Ibaraki
Jaehoon Seol– Student, University of Tsukuba, Tsukuba, Ibaraki
Jue Liu– Student, University of Tsukuba, Tsukuba, Ibaraki
Korin Tateoka– Student, University of Tsukuba, Tsukuba, Ibaraki
Hiroko Isoda– Professor, University of Tsukuba, Tsukua, Ibaraki
Tomohiro Okura– Associate professor, University of Tsukuba, Tsukuba, Ibaraki