Category: Brain Injury; Cross-Cutting
To explore the temporal relationships between depression, anxiety, and cognitive functioning in individuals with moderate-severe traumatic brain injury at one- and two-years post-injury.
Prospective cohort study; we fit a structural equation cross-lagged panel analysis with longitudinal data collected at one- and two-years post-TBI.
Setting : TBI Model Systems (TBIMS) medical centers
Participants (or Animals, Specimens, Cadavers) :
N=168 individuals with moderate-to-severe TBI who received inpatient care at a TBIMS medical center, enrolled in the TBIMS national database from 2013 to 2016.
Interventions : N/A
Main Outcome Measure(s) :
Brief Test of Adult Cognition by Telephone (BTACT); Traumatic Brain Injury - Quality of Life (TBI-QOL) Anxiety and Depression Scales.
Results : A structural equation modeling cross-lagged panel analysis, adjusting for participant characteristics as covariates, revealed cognitive performance at one-year post-injury significantly predicted self-reported anxiety levels at year two (β=-0.14, p=0.005), and tended to be associated with depression at year 2 (β=-0.09, p=0.076).
Cognitive functioning within the first year post-TBI is associated with symptoms of depression and anxiety later in recovery. These results highlight the importance of early cognitive rehabilitation efforts to address post-TBI cognitive challenges as well as to improve psychological adjustment.
Eric Watson– Neuropsychology Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai, New York, New York
Raj Kumar– Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai, New York, New York
Carly Swenson– Clinical Research Coordinator, Icahn School of Medicine at Mount Sinai, New York, New York
Eva Keatley– Intern, University of Washington, Seattle, Washington
Charles Bombardier– Professor, Department of Rehabilitation Medicine, University of Washington, Seattle, Washington
Kristen Dams-O'Connor– Associate Professor of Rehabilitation Medicine and Neurology; Director of Brain Injury Research Center, Icahn School of Medicine at Mount Sinai, New York, New York
Lisa Spielman– Statistician, Icahn School of Medicine at Mount Sinai, New York, New York